Dioclea violacea lectin modulates the gentamicin activity against multi-resistant strains and induces nefroprotection during antibiotic exposure.
Gentamicin is an aminoglycoside antibiotic used to treat infections of various origins. In the last few decades, the constant use of gentamicin has resulted in increased bacterial resistance and nephrotoxicity in some cases. In this study, we examined the ability of Dioclea violacea lectin (DVL) in modulate the antimicrobial activity of gentamicin and reduce the nephrotoxicity induced by this drug.
The minimum inhibitory concentration (MIC) obtained for DVL against all strains studied was not clinically relevant (MIC ≥ 1,024 μg/mL). However, when DVL was combined with gentamicin, a significant increase in antibiotic action was observed against Staphylococcus aureus and Escherichia coli. DVL also reduced antibiotic tolerance in S. aureus during 10 days of continuous treatment.
In addition, DVL presented a nephroprotective effect, reducing sodium excretion, N-Gal expression and urinary protein, that are important markers of glomerular and tubular injuries. Taken together, studies of inhibition of hemagglutinating activity, fluorescence spectroscopy and molecular docking revealed that gentamicin can interact with DVL via the carbohydrate recognition domain (CRD), suggesting that the results obtained in this study may be directly related to the interaction of DVL-gentamicin and with the ability of the lectin to interact with glycans present in the cells of the peritoneum.
Antioxidant, anti-inflammatory, and antiapoptotic effects of virgin coconut oil against antibiotic drug gentamicin-induced nephrotoxicity via the suppression of oxidative stress and modulation of iNOS/NF-ĸB/caspase-3 signaling pathway in Wistar rats.
Gentamicin is an effective antibiotic against severe infections; however, its major side effect is oxidative nephrotoxicity. We explored whether virgin coconut oil (VCO) could mitigate gentamicin-induced nephrotoxicity. Rats were fed with VCO-supplemented diet for 16 days against renal toxicity induced by gentamicin (100 mg/kg bw, ip) from Day 11 to 16. Gentamicin caused marked elevated serum urea, uric acid, and creatinine levels, followed by considerable depletion in renal antioxidant enzymes, glutathione (GSH), while the malondialdehyde (MDA) level increased significantly.
- It significantly increased renal cytokines and nitric oxide (NO) levels, confirmed by renal histopathology. The expression of inducible nitric oxide synthase (iNOS), nuclear factor-kappa B (NF-ĸB), and caspase-3 was prominently increased.
- VCO-supplemented diet significantly modulated the levels of biochemical indices, downregulated the expression of NO, iNOS, NF-ĸB, caspase-3, cytokines, and alleviated histopathological lesions. VCO protects against gentamicin-induced nephrotoxicity; thus, it could be a promising dietary supplement for patients undergoing gentamicin treatment.
- PRACTICAL APPLICATIONS: Gentamicin is an efficacious clinical antibiotic used against severe infections; however, the robust body of evidence indicates that the nephrotoxic side effect constrained its use. Virgin coconut oil (VCO) is an edible oil with growing human consumption and pharmacological effects.
- Our study has reported herein, for the first time, that VCO diet prevented the nephrotoxicity of gentamicin. Dietary supplementation of this oil could be beneficial in alleviating the nephrotoxic side effect of gentamicin in patients.
 Cotinine-BSA Conjugate |
|||
| COTN15-BSA | Alpha Diagnostics | 0.5 mg | EUR 286 |
) Bovine Serum Albumin Biotinylated (Biotin-BSA) |
|||
| BTN-BSA | Alpha Diagnostics | 5 mg | EUR 286 |
 Conjugate) Ibrutinib drug-Bovine Serum Albumin (BSA) Conjugate |
|||
| IBT15-BSA | Alpha Diagnostics | 100 ug | EUR 529 |
-BSA protein Conjugate) Dinitrophenyl (DNP)-BSA protein Conjugate |
|||
| AV-9330-BSA | Alpha Diagnostics | 10 mg | EUR 286 |
 Gentamicin-OVA |
|||
| 80-1455 | Fitzgerald | 1 mg | EUR 651 |
|
Description: OVA conjugated Gentamicin Hapten |
|||
Gentamicin-OVA |
|||
| 80-1456 | Fitzgerald | 1 mg | EUR 651 |
|
Description: OVA conjugated Gentamicin Hapten |
|||
 Gentamicin antibody |
|||
| 20C-CR1031S | Fitzgerald | 1 ml | EUR 219 |
|
Description: Sheep polyclonal Gentamicin antiserum |
|||
Gentamicin antibody |
|||
| 10-1541 | Fitzgerald | 100 ug | EUR 392 |
|
Description: Mouse monoclonal Gentamicin antibody |
|||
Gentamicin antibody |
|||
| 10-G02A | Fitzgerald | 500 ug | EUR 493 |
|
Description: Mouse monoclonal Gentamicin antibody |
|||
Gentamicin antibody |
|||
| 20-GG15 | Fitzgerald | 250 ul | EUR 184 |
|
Description: Goat polyclonal Gentamicin antibody |
|||
Gentamicin antibody |
|||
| 20-GR15 | Fitzgerald | 250 ul | EUR 208 |
|
Description: Rabbit polyclonal Gentamicin antibody |
|||
 Gentamicin-HRP |
|||
| 65-IG10 | Fitzgerald | 1 mg | EUR 597 |
|
Description: Conjugated Gentamicin-HRP hapten |
|||
 Gentamicin sulfate |
|||
| B1270-1G | Biovision | EUR 142 | |
Gentamicin sulfate |
|||
| B1270-25G | Biovision | EUR 947 | |
Gentamicin sulfate |
|||
| B1270-5G | Biovision | EUR 338 | |
 Gentamicin [KLH] |
|||
| DAG4484 | Creative Diagnostics | 1mg | EUR 1040 |
 Gentamicin [HRP] |
|||
| DAGA-032H | Creative Diagnostics | 1mg | EUR 1040 |
) Gentamicin(GM) |
|||
| AT022 | Unibiotest | 1mg | EUR 945 |
) Gentamicin (sulfate) |
|||
| HY-A0276 | MedChemExpress | 500mg | EUR 119 |
Gentamicin(GM) |
|||
| AG022 | Unibiotest | 1 mg | EUR 523 |
 Gentamicin Antibody |
|||
| abx021011-200ug | Abbexa | 200 ug | EUR 328 |
Gentamicin Antibody |
|||
| abx021012-1mg | Abbexa | 1 mg | EUR 954 |
Gentamicin Antibody |
|||
| abx021013-1mg | Abbexa | 1 mg | EUR 481 |
Gentamicin Antibody |
|||
| 20-abx210193 | Abbexa |
|
|
Gentamicin sulfate |
|||
| GA7939-10G | Glentham Life Sciences | 10 g | EUR 102 |
Gentamicin sulfate |
|||
| GA7939-1G | Glentham Life Sciences | 1 g | EUR 46 |
Gentamicin sulfate |
|||
| GA7939-25G | Glentham Life Sciences | 25 g | EUR 158 |
Gentamicin sulfate |
|||
| GA7939-5G | Glentham Life Sciences | 5 g | EUR 78 |
) mPEG-BSA (Molecular Weight: 5,000-linear) |
|||
| PEG-BSA-05K | Alpha Diagnostics | 100 ug | EUR 286 |
) mPEG-BSA (Molecular Weight: 10,000-linear) |
|||
| PEG-BSA-10K | Alpha Diagnostics | 100 ug | EUR 286 |
) mPEG-BSA (Molecular Weight: 20,000-linear) |
|||
| PEG-BSA-20K | Alpha Diagnostics | 100 ug | EUR 286 |
) mPEG-BSA (Molecular Weight: 40,000-linear) |
|||
| PEG-BSA-40K | Alpha Diagnostics | 100 ug | EUR 286 |
 Gentamicin Solution, Gentamicin Solution, 50 mg/mL |
|||
| CCM1123-010 | Bio Basic | 10 mL | EUR 64.05 |
3 peptide (repeat-sequence peptide of the P. vivax circumsporozoite protein, CSP) conjugated with BSA) (DRAAGQPAG)3 peptide (repeat-sequence peptide of the P. vivax circumsporozoite protein, CSP) conjugated with BSA |
|||
| DRAA31-BSA | Alpha Diagnostics | 0.5 mg | EUR 529 |
3 peptide (repeat-sequence peptide of the P. berghei circumsporozoite protein, CSP) conjugated with BSA) (PPPPNAND)3 peptide (repeat-sequence peptide of the P. berghei circumsporozoite protein, CSP) conjugated with BSA |
|||
| PPPP321-BSA | Alpha Diagnostics | 0.5 mg | EUR 529 |
4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) conjugated with BSA) (NVDP)4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) conjugated with BSA |
|||
| NVDP41-BSA | Alpha Diagnostics | 0.5 mg | EUR 529 |
 Gentamicin monoclonal antibody |
|||
| 10R-11497 | Fitzgerald | 1 mg | EUR 1110 |
|
Description: Mouse anti- Gentamicin monoclonal antibody |
|||
 Gentamicin ELISA kit |
|||
| 55R-2233 | Fitzgerald | 1 kit | EUR 698 |
|
Description: Gentamicin ELISA kit for use in research laboratory |
|||
 Gentamicin ELISA Kit |
|||
| K4206-100 | Biovision | EUR 990 | |
 Gentamicin Sulfate USP |
|||
| G006-25G | TOKU-E | 25 g | EUR 392 |
Gentamicin Sulfate USP |
|||
| G006-5G | TOKU-E | 5 g | EUR 166 |
 Gentamicin Sulfate EP |
|||
| G007-25G | TOKU-E | 25 g | EUR 399 |
Gentamicin Sulfate EP |
|||
| G007-5G | TOKU-E | 5 g | EUR 183 |
Gentamicin ELISA Kit |
|||
| DEIA047 | Creative Diagnostics | 96T | EUR 1032 |
|
Description: This kit can be used in quantitative and qualitative analysis of gentamicin residue in vaccine and cell culture. |
|||
 Gentamicin sulfate salt |
|||
| 20-abx082235 | Abbexa |
|
|
 Antibody) Gentamicin (GTM) Antibody |
|||
| 20-abx175177 | Abbexa |
|
|
 Gentamicin, 50mg/ml |
|||
| CA003-001 | GenDepot | 10ml | EUR 91 |
5 peptide (25-aa, repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) conjugated with BSA) (NANP)5 peptide (25-aa, repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) conjugated with BSA |
|||
| NANP51-BSA | Alpha Diagnostics | 0.5 mg | EUR 529 |
 ELISA Kit) Bovine Serum Albumin (BSA) ELISA Kit |
|||
| DLR-BSA-Ge-48T | DL Develop | 48T | EUR 387 |
|
Description: A competitive inhibition quantitative ELISA assay kit for detection of Bovine Serum Albumin (BSA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
|||
Bovine Serum Albumin (BSA) ELISA Kit |
|||
| DLR-BSA-Ge-96T | DL Develop | 96T | EUR 494 |
|
Description: A competitive inhibition quantitative ELISA assay kit for detection of Bovine Serum Albumin (BSA) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
|||
 removal kit (Antibody based aff matrix; sufficient to remove 1-2 mg BSA from Bioprocessed material), 2 ml aff column) Bovine serum albumin (BSA) removal kit (Antibody based aff matrix; sufficient to remove 1-2 mg BSA from Bioprocessed material), 2 ml aff column |
|||
| 800-302-BSA | Alpha Diagnostics | 1 Kit | EUR 347 |
 removal kit (Antibody based aff matrix; sufficient to remove 10-20 mg BSA from Bioprocessed material), 10 ml aff column) Bovine serum albumin (BSA) removal kit (Antibody based aff matrix; sufficient to remove 10-20 mg BSA from Bioprocessed material), 10 ml aff column |
|||
| 800-310-BSA | Alpha Diagnostics | 1 Kit | EUR 895 |
 removal kit (Antibody based aff matrix; sufficient to remove 25-50 mg BSA from Bioprocessed material), 25 ml aff column) Bovine serum albumin (BSA) removal kit (Antibody based aff matrix; sufficient to remove 25-50 mg BSA from Bioprocessed material), 25 ml aff column |
|||
| 800-325-BSA | Alpha Diagnostics | 1 Kit | EUR 1450 |
 ELISA Kit) General Bovine Serum Albumin (BSA) ELISA Kit |
|||
| RD-BSA-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 527 |
General Bovine Serum Albumin (BSA) ELISA Kit |
|||
| RD-BSA-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 732 |
General Bovine Serum Albumin (BSA) ELISA Kit |
|||
| RDR-BSA-Ge-48Tests | Reddot Biotech | 48 Tests | EUR 551 |
General Bovine Serum Albumin (BSA) ELISA Kit |
|||
| RDR-BSA-Ge-96Tests | Reddot Biotech | 96 Tests | EUR 766 |
 Gentamicin C1 pentaacetate salt |
|||
| GA1270-10MG | Glentham Life Sciences | 10 mg | EUR 653 |
Gentamicin C1 pentaacetate salt |
|||
| GA1270-1MG | Glentham Life Sciences | 1 mg | EUR 170 |
 Gentamicin C2 pentaacetate salt |
|||
| GA2476-5MG | Glentham Life Sciences | 5 mg | EUR 349 |
 Gentamicin C1a pentaacetate salt |
|||
| GA4559-10MG | Glentham Life Sciences | 10 mg | EUR 429 |
Gentamicin C1a pentaacetate salt |
|||
| GA4559-25MG | Glentham Life Sciences | 25 mg | EUR 804 |
) Gentamicin ELISA Kit (OKAO00127) |
|||||||||||||
| OKAO00127 | Aviva Systems Biology | 96 Wells | EUR 532 | ||||||||||
|
Description: Description of target: Gentamicin is a complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.;Species reactivity: General;Application: ;Assay info: Assay Methodology: Competitive Inhibition ELISA;Sensitivity:
|
|||||||||||||
, Vaccine adjuvant) Vaccigel Alum adjuvant adsorbed with Bovine Serum Albumin (BSA @1 mg/ml), Vaccine adjuvant |
|||
| AV-1010-BSA | Alpha Diagnostics | 1 ml | EUR 286 |
 standards (1 set) for BCA Optima Protein Assay kit) Pre-diluted BSA (bovine serum albumin) standards (1 set) for BCA Optima Protein Assay kit |
|||
| BCA-BSA-1 | Alpha Diagnostics | 1 pk | EUR 164 |
 standards (750 ug/ml) for BCA Optima Protein Assay kit) Pre-diluted BSA (bovine serum albumin) standards (750 ug/ml) for BCA Optima Protein Assay kit |
|||
| BCA-BSA-750 | Alpha Diagnostics | 1 ml | EUR 225 |
 for BCA Optima Protein Assay kit) BSA and BGG Stock standards (1 vial each @ 2 mg/ml) for BCA Optima Protein Assay kit |
|||
| BSA-BGG-1 | Alpha Diagnostics | 1 pk | EUR 286 |
 ELISA Kit) Gentamicin (serum/urine) ELISA Kit |
|||
| K4315-100 | Biovision | EUR 756 | |
 Gentamicin C1 Sulfate EvoPure® |
|||
| G031-10MG | TOKU-E | 10 mg | EUR 670 |
 Gentamicin C1a sulfate EvoPure® |
|||
| G032-10MG | TOKU-E | 10 mg | EUR 670 |
 Gentamicin C2 sulfate EvoPure® |
|||
| G033-10MG | TOKU-E | 10 mg | EUR 670 |
 Gentamicin C2a sulfate EvoPure® |
|||
| G034-10MG | TOKU-E | 10 mg | EUR 670 |
 Gentamicin A sulfate EvoPure® |
|||
| G035-10MG | TOKU-E | 10 mg | EUR 380 |
 Gentamicin X2 sulfate EvoPure® |
|||
| G036-2.5MG | TOKU-E | 2.5 mg | EUR 30 |
Gentamicin X2 sulfate EvoPure® |
|||
| G036-PleaseContactusforPricing | TOKU-E | Please Contact us for Pricing | EUR 30 |
 Gentamicin C2b sulfate EvoPure® |
|||
| G062-10MG | TOKU-E | 10 mg | EUR 513 |
 Mouse Anti Gentamicin Monoclonal Antibody |
|||
| DMABT-54913MG | Creative Diagnostics | 1 mg | EUR 767 |
Mouse Anti Gentamicin Monoclonal Antibody |
|||
| DMABT-54914MG | Creative Diagnostics | 1 mg | EUR 767 |
Gentamicin, azithromycin and ceftriaxone in the treatment of gonorrhoea: the relationship between antibiotic MIC and clinical outcome.
To investigate the relationship between MIC and clinical outcome in a randomized controlled trial that compared gentamicin 240 mg plus azithromycin 1 g with ceftriaxone 500 mg plus azithromycin 1 g. MIC analysis was performed on Neisseria gonorrhoeae isolates from all participants who were culture positive before they received treatment.
Viable gonococcal cultures were available from 279 participants, of whom 145 received ceftriaxone/azithromycin and 134 received gentamicin/azithromycin. Four participants (6 isolates) and 14 participants (17 isolates) did not clear infection in the ceftriaxone/azithromycin and gentamicin/azithromycin arms, respectively. MICs were determined by Etest on GC agar base with 1% Vitox.
The geometric mean MICs of azithromycin, ceftriaxone and gentamicin were compared using logistic and linear regression according to treatment received and N. gonorrhoeae clearance.As the azithromycin MIC increased, gentamicin/azithromycin treatment was less effective than ceftriaxone/azithromycin at clearing N. gonorrhoeae.
There was a higher geometric mean MIC of azithromycin for isolates from participants who had received gentamicin/azithromycin and did not clear infection compared with those who did clear infection [ratio 1.95 (95% CI 1.28-2.97)], but the use of categorical MIC breakpoints did not accurately predict the treatment response.
The geometric mean MIC of azithromycin was higher in isolates from the pharynx compared with genital isolates.We found that categorical resistance to azithromycin or ceftriaxone in vitro, and higher gentamicin MICs in the absence of breakpoints, were poorly predictive of treatment failure.
Gentamicin sulfate |
|||
| GA7939-1G | Glentham Life Sciences | 1 g | EUR 46 |
Gentamicin sulfate |
|||
| GA7939-25G | Glentham Life Sciences | 25 g | EUR 158 |
Gentamicin sulfate |
|||
| GA7939-5G | Glentham Life Sciences | 5 g | EUR 78 |
Gentamicin Sulfate USP |
|||
| G006-25G | TOKU-E | 25 g | EUR 392 |
Gentamicin Sulfate USP |
|||
| G006-5G | TOKU-E | 5 g | EUR 166 |
Gentamicin Sulfate EP |
|||
| G007-25G | TOKU-E | 25 g | EUR 399 |
Gentamicin Sulfate EP |
|||
| G007-5G | TOKU-E | 5 g | EUR 183 |
Gentamicin C1 pentaacetate salt |
|||
| GA1270-10MG | Glentham Life Sciences | 10 mg | EUR 653 |
Gentamicin C1 pentaacetate salt |
|||
| GA1270-1MG | Glentham Life Sciences | 1 mg | EUR 170 |
Gentamicin C2 pentaacetate salt |
|||
| GA2476-5MG | Glentham Life Sciences | 5 mg | EUR 349 |
Gentamicin C1a pentaacetate salt |
|||
| GA4559-10MG | Glentham Life Sciences | 10 mg | EUR 429 |
Gentamicin C1a pentaacetate salt |
|||
| GA4559-25MG | Glentham Life Sciences | 25 mg | EUR 804 |
Gentamicin C1 Sulfate EvoPure® |
|||
| G031-10MG | TOKU-E | 10 mg | EUR 670 |
Gentamicin C1a sulfate EvoPure® |
|||
| G032-10MG | TOKU-E | 10 mg | EUR 670 |
Gentamicin C2 sulfate EvoPure® |
|||
| G033-10MG | TOKU-E | 10 mg | EUR 670 |
Gentamicin C2a sulfate EvoPure® |
|||
| G034-10MG | TOKU-E | 10 mg | EUR 670 |
Gentamicin A sulfate EvoPure® |
|||
| G035-10MG | TOKU-E | 10 mg | EUR 380 |
Gentamicin X2 sulfate EvoPure® |
|||
| G036-2.5MG | TOKU-E | 2.5 mg | EUR 30 |
Gentamicin X2 sulfate EvoPure® |
|||
| G036-PleaseContactusforPricing | TOKU-E | Please Contact us for Pricing | EUR 30 |
Gentamicin C2b sulfate EvoPure® |
|||
| G062-10MG | TOKU-E | 10 mg | EUR 513 |
 0.1 G GENTAMICIN SULFATE, POWDER |
|||
| 61-098-RA | CORNING | 0,1 g/pk | EUR 62 |
|
Description: Media Catalog; Cell Culture Reagents |
|||
 1 G GENTAMICIN SULFATE, POWDER |
|||
| 61-098-RF | CORNING | 1 g/pk | EUR 58 |
|
Description: Media Catalog; Cell Culture Reagents |
|||
 Streptomycin sulfate salt |
|||
| 20-abx082471 | Abbexa |
|
|
Streptomycin sulfate salt |
|||
| 20-abx082589 | Abbexa |
|
|
 Colistin sulfate salt |
|||
| GA9867-1G | Glentham Life Sciences | 1 g | EUR 110 |
Colistin sulfate salt |
|||
| GA9867-500MG | Glentham Life Sciences | 500 mg | EUR 78 |
 Netilmicin sulfate salt |
|||
| GA1999-100MG | Glentham Life Sciences | 100 mg | EUR 62 |
Netilmicin sulfate salt |
|||
| GA1999-1G | Glentham Life Sciences | 1 g | EUR 156 |
Netilmicin sulfate salt |
|||
| GA1999-250MG | Glentham Life Sciences | 250 mg | EUR 86 |
 Paromomycin sulfate salt |
|||
| GA4947-1G | Glentham Life Sciences | 1 g | EUR 54 |
Paromomycin sulfate salt |
|||
| GA4947-25G | Glentham Life Sciences | 25 g | EUR 229 |
Paromomycin sulfate salt |
|||
| GA4947-5G | Glentham Life Sciences | 5 g | EUR 94 |
Streptomycin sulfate salt |
|||
| GA7700-100G | Glentham Life Sciences | 100 g | EUR 78 |
Streptomycin sulfate salt |
|||
| GA7700-25G | Glentham Life Sciences | 25 g | EUR 50 |
Streptomycin sulfate salt |
|||
| GA7700-50G | Glentham Life Sciences | 50 g | EUR 62 |
Streptomycin sulfate salt |
|||
| GA7700-5G | Glentham Life Sciences | 5 g | EUR 44 |
 Ribostamycin sulfate salt |
|||
| GA7826-1G | Glentham Life Sciences | 1 g | EUR 229 |
Ribostamycin sulfate salt |
|||
| GA7826-250MG | Glentham Life Sciences | 250 mg | EUR 110 |
 Sisomicin sulfate salt |
|||
| GA7855-1G | Glentham Life Sciences | 1 g | EUR 142 |
Sisomicin sulfate salt |
|||
| GA7855-250MG | Glentham Life Sciences | 250 mg | EUR 78 |
Sisomicin sulfate salt |
|||
| GA7855-5G | Glentham Life Sciences | 5 g | EUR 341 |
 Apramycin sulfate salt |
|||
| GA8829-1G | Glentham Life Sciences | 1 g | EUR 50 |
Apramycin sulfate salt |
|||
| GA8829-25G | Glentham Life Sciences | 25 g | EUR 118 |
Apramycin sulfate salt |
|||
| GA8829-5G | Glentham Life Sciences | 5 g | EUR 62 |
Colistin sulfate salt |
|||
| GA9867-100MG | Glentham Life Sciences | 100 mg | EUR 54 |
Colistin sulfate salt |
|||
| GA9867-5G | Glentham Life Sciences | 5 g | EUR 309 |
 CYT387 sulfate salt |
|||
| A3339-10 | ApexBio | 10 mg | EUR 177 |
|
Description: CYT387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively. CYT387 is useful for treatment of myeloproliferative disorders and anti-cancer. |
|||
CYT387 sulfate salt |
|||
| A3339-200 | ApexBio | 200 mg | EUR 943 |
|
Description: CYT387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively. CYT387 is useful for treatment of myeloproliferative disorders and anti-cancer. |
|||
CYT387 sulfate salt |
|||
| A3339-5 | ApexBio | 5 mg | EUR 142 |
|
Description: CYT387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively. CYT387 is useful for treatment of myeloproliferative disorders and anti-cancer. |
|||
CYT387 sulfate salt |
|||
| A3339-50 | ApexBio | 50 mg | EUR 398 |
|
Description: CYT387 is an ATP-competitive small molecule JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM for JAK1 and JAK2, respectively. CYT387 is useful for treatment of myeloproliferative disorders and anti-cancer. |
|||
 Minoxidil sulfate salt |
|||
| GP8215-100MG | Glentham Life Sciences | 100 mg | EUR 78 |
Minoxidil sulfate salt |
|||
| GP8215-1G | Glentham Life Sciences | 1 g | EUR 136 |
 Dodecyl sulfate sodium salt |
|||
| abx185405-500g | Abbexa | 500 g | EUR 356 |
 Polymixin B sulfate salt |
|||
| GA4910-10G | Glentham Life Sciences | 10 g | EUR 269 |
Polymixin B sulfate salt |
|||
| GA4910-1G | Glentham Life Sciences | 1 g | EUR 86 |
Polymixin B sulfate salt |
|||
| GA4910-5G | Glentham Life Sciences | 5 g | EUR 174 |
 Dextran sulfate sodium salt |
|||
| B8205-100000 | ApexBio | 100 g | EUR 514 |
Dextran sulfate sodium salt |
|||
| B8205-500000 | ApexBio | 500 g | EUR 1442 |
) Gentamicin Sulfate Solution (50 mg/mL in Water) |
|||
| G046-20ML | TOKU-E | 20 mL | EUR 110 |
 DHEA 3 Sulfate Sodium Salt |
|||
| 30-AD25 | Fitzgerald | 1 gram | EUR 344 |
|
Description: DHEA 3 Sulfate Sodium Salt |
|||
 Chondroitin sulfate A sodium salt |
|||
| GC6763-100G | Glentham Life Sciences | 100 g | EUR 198 |
Chondroitin sulfate A sodium salt |
|||
| GC6763-10G | Glentham Life Sciences | 10 g | EUR 58 |
Chondroitin sulfate A sodium salt |
|||
| GC6763-25G | Glentham Life Sciences | 25 g | EUR 85 |
Chondroitin sulfate A sodium salt |
|||
| GC6763-50G | Glentham Life Sciences | 50 g | EUR 126 |
Chondroitin sulfate A sodium salt |
|||
| GC6763-5G | Glentham Life Sciences | 5 g | EUR 50 |
 10 ML GENTAMICIN SULFATE, LIQUID 50 MG/ML SOLUTION |
|||
| 30-005-CR | CORNING | 10 mL/pk | EUR 433 |
|
Description: Media Catalog; Cell Culture Reagents |
|||
 Gentamicin-BSA |
|||
| 80-1453 | Fitzgerald | 1 mg | EUR 651 |
|
Description: BSA conjugated Gentamicin Hapten |
|||
Gentamicin-BSA |
|||
| 80-1454 | Fitzgerald | 1 mg | EUR 651 |
|
Description: BSA conjugated Gentamicin Hapten |
|||
Gentamicin-OVA |
|||
| 80-1455 | Fitzgerald | 1 mg | EUR 651 |
|
Description: OVA conjugated Gentamicin Hapten |
|||
Gentamicin-OVA |
|||
| 80-1456 | Fitzgerald | 1 mg | EUR 651 |
|
Description: OVA conjugated Gentamicin Hapten |
|||
Gentamicin-BSA |
|||
| 80-IG10 | Fitzgerald | 25 mg | EUR 381 |
|
Description: Conjugated Gentamicin-BSA hapten |
|||
Gentamicin antibody |
|||
| 20C-CR1031S | Fitzgerald | 1 ml | EUR 219 |
|
Description: Sheep polyclonal Gentamicin antiserum |
|||
Gentamicin antibody |
|||
| 10-1541 | Fitzgerald | 100 ug | EUR 392 |
|
Description: Mouse monoclonal Gentamicin antibody |
|||
Gentamicin antibody |
|||
| 10-G02A | Fitzgerald | 500 ug | EUR 493 |
|
Description: Mouse monoclonal Gentamicin antibody |
|||
Gentamicin antibody |
|||
| 20-GG15 | Fitzgerald | 250 ul | EUR 184 |
|
Description: Goat polyclonal Gentamicin antibody |
|||
Gentamicin antibody |
|||
| 20-GR15 | Fitzgerald | 250 ul | EUR 208 |
|
Description: Rabbit polyclonal Gentamicin antibody |
|||
Gentamicin-HRP |
|||
| 65-IG10 | Fitzgerald | 1 mg | EUR 597 |
|
Description: Conjugated Gentamicin-HRP hapten |
|||
