Function: This evaluate aimed to guage the consequences of the native supply of antibiotics integrated in implant surfaces on some quantitative parameters of bone formation.
Supplies and strategies: An digital search was undertaken in three databases (PubMed, Scopus, Embase) along with hand looking out. The search was restricted to animal experiments utilizing endosseous implants mixed with localized antibiotics launch. Meta-analyses have been carried out for the chances of bone quantity (BV) and bone-to-implant contact (BIC).
Outcomes: 9 research met the inclusion standards. A number of strategies have been recognized for native supply of antibiotics on the bone-implant interface, however essentially the most generally used technique was by coating (incorporating the implant floor with the antibiotic brokers). Totally different antibiotic brokers have been used, particularly bacitracin, doxycycline, enoxacin, gentamicin, minocycline, tobramycin, and vancomycin. There was no statistically important distinction within the share of BIC between implants with or with out localized antibiotic launch (P = 0.59). The meta-analysis revealed increased BV round implants coated with antibiotics in comparison with management teams (with out antibiotics) (P < 0.01).
Conclusion: It’s prompt that the native administration of antibiotics round implants didn’t adversely have an effect on the share of direct bone contact round implants, with a bent for a barely higher bone formation round implants when mixed with native administration of antibiotics. It’s a matter of debate whether or not these in vivo outcomes may have the identical impact within the medical setting. Nevertheless, the chance of bias of those research could, to some extent, query the validity of those outcomes.
Dissociating antibacterial from ototoxic results of gentamicin C-subtypes
Gentamicin is a potent broad-spectrum aminoglycoside antibiotic whose use is hampered by ototoxic side-effects. Hospital gentamicin is a mix of 5 gentamicin C-subtypes and several other impurities of varied ranges of nonexact concentrations. We developed a purification technique enabling assaying of particular person C-subtypes and impurities for ototoxicity and antimicrobial exercise. We discovered that C-subtypes displayed broad and potent in vitro antimicrobial actions corresponding to the hospital gentamicin combination. In distinction, they confirmed completely different levels of ototoxicity in cochlear explants, with gentamicin C2b being the least and gentamicin C2 essentially the most ototoxic.
Construction-activity relationships recognized websites within the C4′-C6′ area on ring I that diminished ototoxicity whereas preserving antimicrobial exercise, thus figuring out targets for future drug design and mechanisms for hair cell toxicity. Construction-activity relationship knowledge prompt and electrophysiological knowledge confirmed that the C-subtypes each bind and permeate the hair cell mechanotransducer channel, with the stronger the binding the much less ototoxic the compound. Lastly, each particular person and reformulated mixtures of C-subtypes demonstrated decreased ototoxicity whereas sustaining antimicrobial exercise, thereby serving as a proof-of-concept of drug reformulation to minimizing ototoxicity of gentamicin in sufferers.
Recurrent obstructive uropathy secondary to pyometrocolpos in an 8-month-old toddler: a case report
Background: Pyometrocolpos is accumulation of contaminated fluid within the uterus and vagina. It’s uncommon in kids, largely seen after menarche on account of obstructive congenital genital malformation that impairs free drainage of the uterine secretions. In a baby, it could current as an acute sickness that necessitates pressing and applicable administration and remedy of the underlying trigger, which could be a problem in a resource-limited setting.
Case presentation: We report a case of pyometrocolpos in an 8-month-old African toddler who introduced with fever, vomiting, decreased urine output, and belly distension of 12 days’ period. An belly examination revealed a subumbilical midline incision scar and a midline decrease belly mass. She appeared to have introduced on the emergency division with related complaints 2 months earlier and had been recognized with pyometra, which was managed by emergency laparotomy for pus drainage, and she or he was stored on antibiotics. Restoration was established after 10 days of admission, and the affected person was discharged to residence. Her signs reappeared 2 months after the primary presentation. Her blood work confirmed important leukocytosis with neutrophilia, and belly ultrasound depicted bilateral hydronephrosis with hydroureters and a fluid-filled uterus. Examination below anesthesia within the working theater revealed normal-looking feminine genitalia with a cribriform hymen, beneath which lied a transverse vaginal septum. Foul-smelling pus was aspirated by way of the septum, and septectomy was carried out to permit 350 ml of pus to empty. A pus pattern was despatched for tradition and sensitivity, and Escherichia coli delicate to ceftriaxone and gentamicin was remoted.
OVA conjugated Gentamicin Hapten |
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| MBS5308014-1mg | MyBiosource | 1mg | EUR 930 |
OVA conjugated Gentamicin Hapten |
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| MBS5308014-5x1mg | MyBiosource | 5x1mg | EUR 4035 |
Gentamicin-OVA Conjugate |
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| MBS7115392-1mg | MyBiosource | 1mg | EUR 490 |
Gentamicin-OVA Conjugate |
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| MBS7115392-5x1mg | MyBiosource | 5x1mg | EUR 2150 |
Gentamicin-OVA Conjugate |
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| MBS7115393-1mg | MyBiosource | 1mg | EUR 490 |
Gentamicin-OVA Conjugate |
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| MBS7115393-5x1mg | MyBiosource | 5x1mg | EUR 2150 |
Gentamicin |
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| EM061-150ST | EWC Diagnostics | 1 unit | EUR 169.41 |
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Description: Gentamicin |
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Gentamicin |
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| EM025-150ST | EWC Diagnostics | 1 unit | EUR 164.38 |
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Description: Gentamicin |
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Gentamicin |
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| G272 | ABM | 10ml | EUR 70 |
Gentamicin |
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| HY-A0276A | MedChemExpress | Get quote | Ask for price |
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Description: Gentamicin, an orally active aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits DNase I with an IC50 of 0.57 mM[1][2][3][4]. |
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Gentamicin |
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| MBS5775176-5mg | MyBiosource | 5(mg | EUR 915 |
Gentamicin |
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| MBS5775176-5x5mg | MyBiosource | 5x5(mg | EUR 3970 |
Gentamicin |
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| MD025-1PK | EWC Diagnostics | 1 unit | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| MD061-1PK | EWC Diagnostics | 1 unit | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| T25447-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| T25447-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| T25447-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| T25447-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| T25447-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Gentamicin |
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Gentamicin Solution, Gentamicin Solution, 50 mg/mL |
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| CCM1123-010 | Bio Basic | 10 mL | EUR 76.86 |
Gentamicin(GM) |
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| AT022 | Unibiotest | 1mg | EUR 1134 |
Gentamicin(GM) |
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| AG022 | Unibiotest | 1 mg | EUR 627.6 |
Gentamicin (PE) |
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| MBS6251839-01mL | MyBiosource | 0.1(mL | EUR 880 |
Gentamicin (PE) |
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| MBS6251839-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamicin (AP) |
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| MBS6247946-01mL | MyBiosource | 0.1(mL | EUR 880 |
Gentamicin (AP) |
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| MBS6247946-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamycin (Gentamicin) |
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| MBS614836-025mL | MyBiosource | 0.25mL | EUR 490 |
Gentamycin (Gentamicin) |
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| MBS614836-5x025mL | MyBiosource | 5x0.25mL | EUR 2055 |
Gentamycin (Gentamicin) |
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| MBS615263-025mL | MyBiosource | 0.25mL | EUR 515 |
Gentamycin (Gentamicin) |
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| MBS615263-5x025mL | MyBiosource | 5x0.25mL | EUR 2155 |
Gentamycin (Gentamicin) |
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| MBS605789-1mg | MyBiosource | 1mg | EUR 530 |
Gentamycin (Gentamicin) |
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| MBS605789-5x1mg | MyBiosource | 5x1mg | EUR 2230 |
Gentamycin (Gentamicin) |
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| MBS614871-1mg | MyBiosource | 1mg | EUR 450 |
Gentamycin (Gentamicin) |
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| MBS614871-5x1mg | MyBiosource | 5x1mg | EUR 1865 |
Gentamycin (Gentamicin) |
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| MBS600426-025mg | MyBiosource | 0.25mg | EUR 580 |
Gentamycin (Gentamicin) |
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| MBS600426-05mg | MyBiosource | 0.5mg | EUR 965 |
Gentamycin (Gentamicin) |
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| MBS600426-5x05mg | MyBiosource | 5x0.5mg | EUR 4185 |
Gentamycin (Gentamicin) |
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| MBS603541-05mg | MyBiosource | 0.5mg | EUR 1285 |
Gentamycin (Gentamicin) |
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| MBS603541-5x05mg | MyBiosource | 5x0.5mg | EUR 5640 |
Gentamicin [KLH] |
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| DAG4484 | Creative Diagnostics | 1mg | EUR 834.75 |
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Description: Synthetic |
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Gentamicin [HRP] |
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| DAGA-032H | Creative Diagnostics | 1mg | EUR 834.75 |
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Description: Synthetic |
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Gentamicin C1a |
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| HY-148286 | MedChemExpress | 10 mg | EUR 77.92 |
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Description: Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2]. |
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Gentamicin (HRP) |
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| MBS6250887-01mL | MyBiosource | 0.1(mL | EUR 880 |
Gentamicin (HRP) |
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| MBS6250887-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamicin (APC) |
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| MBS6268799-01mL | MyBiosource | 0.1mL | EUR 880 |
Gentamicin (APC) |
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| MBS6268799-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamicin (FITC) |
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| MBS6249892-01mL | MyBiosource | 0.1(mL | EUR 880 |
Gentamicin (FITC) |
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| MBS6249892-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamicin-HRP |
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| 65-IG10 | Fitzgerald | 1 mg | EUR 525 |
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Description: Conjugated Gentamicin-HRP hapten |
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Gentamicin-BSA |
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| 80-1453 | Fitzgerald | 1 mg | EUR 592 |
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Description: BSA conjugated Gentamicin Hapten |
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Gentamicin-BSA |
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| 80-1454 | Fitzgerald | 1 mg | EUR 592 |
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Description: BSA conjugated Gentamicin Hapten |
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Gentamicin-BSA |
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| 80-IG10 | Fitzgerald | 25 mg | EUR 325 |
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Description: Conjugated Gentamicin-BSA hapten |
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Gentamicin-BSA |
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| MBS537343-25mg | MyBiosource | 25mg | EUR 505 |
Gentamicin-BSA |
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| MBS537343-5x25mg | MyBiosource | 5x25mg | EUR 2115 |
Gentamicin-HRP |
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| MBS537743-1mg | MyBiosource | 1mg | EUR 680 |
Gentamicin-HRP |
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| MBS537743-5x1mg | MyBiosource | 5x1mg | EUR 2915 |
Gentamicin-BSA |
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| MBS7041680-01mg | MyBiosource | 0.1mg | EUR 135 |
Gentamicin-BSA |
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| MBS7041680-1mg | MyBiosource | 1mg | EUR 435 |
Gentamicin-BSA |
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| MBS7041680-5x1mg | MyBiosource | 5x1mg | EUR 1915 |
Gentamicin (Biotin) |
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| MBS6248965-01mL | MyBiosource | 0.1(mL | EUR 880 |
Gentamicin (Biotin) |
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| MBS6248965-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamicin Sulfate |
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| 40710020-1 | Bio-WORLD | 5 g | EUR 36.51 |
Gentamicin Sulfate |
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| 40710020-2 | Bio-WORLD | 10 g | EUR 61.99 |
Gentamicin Sulfate |
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| 40710020-3 | Bio-WORLD | 25 g | EUR 117.28 |
Gentamicin Sulfate |
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| 16637-32 | NACALAI TESQUE | 25G | EUR 630 |
Gentamicin Sulfate |
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| 08975-81 | NACALAI TESQUE | 1G | EUR 77 |
Gentamicin Sulfate |
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| 08975-94 | NACALAI TESQUE | 5G | EUR 266 |
Gentamicin sulfate |
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| 329895 | MedKoo Biosciences | 1.0g | EUR 250 |
Gentamicin sulfate |
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| B1270-1G | Biovision | each | EUR 170.4 |
Gentamicin sulfate |
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| B1270-25G | Biovision | each | EUR 1136.4 |
Gentamicin sulfate |
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| B1270-5G | Biovision | each | EUR 405.6 |
GENTAMICIN SULFATE |
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| G570 | PhytoTechnology Laboratories | 10G | EUR 32.75 |
Gentamicin sulfate |
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| GA7939 | Glentham Life Sciences | 1g | EUR 115.8 |
Gentamicin sulfate |
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| GA7939-1 | Glentham Life Sciences | 1 | EUR 15.9 |
Gentamicin sulfate |
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| GA7939-10 | Glentham Life Sciences | 10 | EUR 71.1 |
Gentamicin sulfate |
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| GA7939-10G | Glentham Life Sciences | 10 g | EUR 122.4 |
Gentamicin sulfate |
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| GA7939-1G | Glentham Life Sciences | 1 g | EUR 55.2 |
Gentamicin sulfate |
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| GA7939-25 | Glentham Life Sciences | 25 | EUR 126.5 |
Gentamicin sulfate |
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| GA7939-25G | Glentham Life Sciences | 25 g | EUR 189.6 |
Gentamicin sulfate |
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| GA7939-5 | Glentham Life Sciences | 5 | EUR 47.4 |
Gentamicin sulfate |
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| GA7939-5G | Glentham Life Sciences | 5 g | EUR 93.6 |
Gentamicin (sulfate) |
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| HY-A0276 | MedChemExpress | 500mg | EUR 64.94 |
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Description: Gentamicin sulfate, an orally active aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits DNase I with an IC50 of 0.57 mM[1][2][3][4]. |
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Gentamicin sulfate |
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| T1326-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Gentamicin sulfate |
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Gentamicin sulfate |
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| T1326-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Gentamicin sulfate |
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Gentamicin sulfate |
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| T1326-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Gentamicin sulfate |
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Gentamicin sulfate |
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| T1326-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Gentamicin sulfate |
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Gentamicin sulfate |
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| T1326-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Gentamicin sulfate |
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Gentamicin Antibody |
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| abx021011-200ug | Abbexa | 200 ug | EUR 393.6 |
Gentamicin Antibody |
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| abx021012-1mg | Abbexa | 1 mg | EUR 1144.8 |
Gentamicin Antibody |
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| abx021012-400l | Abbexa | 400 µl | Ask for price |
Gentamicin Antibody |
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| abx021012-80l | Abbexa | 80 µl | EUR 2012.5 |
Gentamicin Antibody |
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| abx021013-1mg | Abbexa | 1 mg | EUR 577.2 |
Gentamicin antibody |
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| 20C-CR1031S | Fitzgerald | 1 ml | EUR 174 |
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Description: Sheep polyclonal Gentamicin antiserum |
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Gentamicin antibody |
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| 10-1541 | Fitzgerald | 100 ug | EUR 350 |
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Description: Mouse monoclonal Gentamicin antibody |
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Gentamicin antibody |
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| 10-G02A | Fitzgerald | 500 ug | EUR 231.75 |
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Description: Mouse monoclonal Gentamicin antibody |
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Gentamicin antibody |
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| 20-GG15 | Fitzgerald | 250 ul | Ask for price |
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Description: Goat polyclonal Gentamicin antibody |
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Gentamicin antibody |
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| 20-GR15 | Fitzgerald | 250 ul | EUR 165 |
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Description: Rabbit polyclonal Gentamicin antibody |
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Gentamicin sulphate |
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| CMS461-1G | EWC Diagnostics | 1 unit | EUR 8.67 |
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Description: Gentamicin sulphate |
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Gentamicin sulphate |
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| CMS461-5G | EWC Diagnostics | 1 unit | EUR 39.01 |
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Description: Gentamicin sulphate |
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Gentamicin Antibody |
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| abx210193-100l | Abbexa | 100 µl | EUR 400 |
Gentamicin Antibody |
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| 20-abx210193 | Abbexa |
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Gentamicin Antibody |
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| abx210193-50l | Abbexa | 50 µl | EUR 281.25 |
Gentamicin Antibody |
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| GWB-5E5C0A | GenWay Biotech | 1 ml | Ask for price |
Gentamicin Antibody |
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| GWB-5F0BB2 | GenWay Biotech | 1 mg | Ask for price |
Gentamicin Antibody |
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| GWB-300476 | GenWay Biotech | 0.2 mg | Ask for price |
Gentamicin, Antibody |
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| GWB-F36A07 | GenWay Biotech | 1 mg | Ask for price |
Gentamicin Antibody |
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| GWB-C38937 | GenWay Biotech | 0.2 mg | Ask for price |
Gentamicin Antibody |
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| GWB-Q00939 | GenWay Biotech | 1 mg | Ask for price |
Gentamicin Antibody |
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| GWB-Q00940 | GenWay Biotech | 1 mg | Ask for price |
Gentamicin Antibody |
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| MBS568270-1mg | MyBiosource | 1mg | EUR 330 |
Gentamicin Antibody |
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| MBS568270-5x1mg | MyBiosource | 5x1mg | EUR 1280 |
Gentamicin antibody |
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| MBS531696-05mg | MyBiosource | 0.5mg | EUR 980 |
Gentamicin antibody |
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| MBS531696-5x05mg | MyBiosource | 5x0.5mg | EUR 4255 |
Gentamicin antibody |
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| MBS534638-025mL | MyBiosource | 0.25mL | EUR 275 |
Gentamicin antibody |
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| MBS534638-5x025mL | MyBiosource | 5x0.25mL | EUR 1075 |
Gentamicin antibody |
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| MBS535388-025mL | MyBiosource | 0.25mL | EUR 245 |
Gentamicin antibody |
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| MBS839093-1mL | MyBiosource | 1mL | EUR 280 |
Gentamicin antibody |
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| MBS839093-5x1mL | MyBiosource | 5x1mL | EUR 1110 |
Gentamicin sulphate |
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| PCT1118-10G | EWC Diagnostics | 1 unit | EUR 85.92 |
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Description: Gentamicin sulphate |
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Gentamicin sulphate |
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| PCT1118-25G | EWC Diagnostics | 1 unit | EUR 212.21 |
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Description: Gentamicin sulphate |
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Gentamycin (Gentamicin) (AP) |
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| MBS6260167-01mL | MyBiosource | 0.1mL | EUR 840 |
Gentamycin (Gentamicin) (AP) |
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| MBS6260167-5x01mL | MyBiosource | 5x0.1mL | EUR 3625 |
Conclusion: Pyometrocolpos is uncommon in childhood however needs to be suspected in a woman presenting with a midline decrease belly mass accompanied with urinary obstructive signs related to fever and gastrointestinal signs. Escherichia coli appears to be essentially the most possible offending organism, however pus tradition is essential for antibiotic stewardship in correct administration of the an infection. Definitive remedy ought to concentrate on correcting the obstructive anatomical congenital deformity that precipitated the obstruction to be able to keep away from recurrence.
