Hematological, biochemical and hematopoietic results of therapeutic doses of two antibiotics, oxytetracycline (OTC) and gentamicin (GEN), in clinically wholesome frequent carp juveniles have been studied. The fish have been divided into 4 teams: controls 1 and a pair of (untreated or injected with 0.6% NaCl resolution), and two teams handled with antibiotics (orally with 75 mg/kg OTC 4 instances each two days or injected with a single dose (four mg/kg) of GEN dissolved in 0.6% NaCl). Blood and head kidneys have been sampled from all fish three days post-treatments for hematological, biochemical and hematopoietic tissue analyses. No main alterations within the values of hematological and serum biochemical parameters occurred following administration of OTC or GEN. Glucose concentrations have been considerably decrease in each teams of fish subjected to injections (Management 2 and GEN), whereas the oxidative metabolic exercise of phagocytes elevated within the antibiotic-treated teams (considerably in OTC).
Extra alterations have been noticed in hematopoietic tissue. Immunocytochemical evaluation revealed that G triggered a big enhance within the price of cell proliferation (PCNA-positive cells) and a rise within the frequency of apoptotic cells (caspase-positive). The frequency of lymphoid lineage decreased, which was associated to a lower within the abundance of mature lymphocytes in GEN-treated fish. Percentages of neutrophilic lineage have been considerably elevated in OTC and GEN teams in comparison with controls. The obtained outcomes confirmed no appreciable hematotoxicity or hepatotoxicity of therapeutic doses of OTC and GEN to carp. MicroRNAs function potential biomarkers in varied pathological fashions, and are steady and detectable in biofluids. We investigated the urinary microRNA expression profile in a gentamicin-induced acute kidney harm canine mannequin utilizing RNA sequencing. A complete of 234 differentially expressed microRNAs have been screened after 12 consecutive days of gentamicin administration (P < 0.05).
This examine investigated antimicrobial resistance (AMR) profiles from a cohort of sufferers with bacterial keratitis handled at Sydney Eye Hospital, 1 January 2017 – 31 December 2018. These AMR profiles have been analysed within the context of the present Australian empiric regimens for topical remedy: ciprofloxacin/ofloxacin monotherapy versus mixture remedy of cefalotin/cephazolin plus gentamicin. At our Centre, combos of (i) chloramphenicol plus gentamicin and (ii) chloramphenicol plus ciprofloxacin are alternatively used, so have been additionally analysed. 300 and seventy-four isolates have been cultured prospectively: 280/374 (75%) have been gram optimistic, and 94/374 (25%) have been gram destructive.
Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity forestall and reverse rifampin resistance in Gram-negative micro organism
The rising prevalence of antibiotic resistance in Gram-negative micro organism requires the invention of novel efficient therapeutic methods urgently. Mastoparan-C (MP-C), a typical cationic α-helical antimicrobial peptide, possesses outstanding broad-spectrum antimicrobial exercise. Nevertheless, its excessive cytotoxicity towards regular mammalian cells precludes it for additional improvement. On this examine, to keep away from non-specific membrane lysis and examine the structure-function relationships of every amino acid of MP-C, a sequence of latest MP-C analogs have been rationally designed by amino acid substitution and peptide truncation. Three potential newly designed peptides L1G, L7A, and L1GA5Okay with wonderful bioactivity, modest cell toxicity, low resistance tendency, and reasonable stability to physiological salts and proteases have been screened out.
Furthermore, the newly designed peptides confirmed synergy or additive results towards Gram-negative micro organism, after they mixed with standard antibiotics gentamicin, rifampin, and polymyxin B. The outcomes from the time-kill kinetics, outer/inside membrane permeabilization, scanning electron microscope (SEM), and movement cytometry demonstrated that the newly designed peptides might kill micro organism quickly by membrane destruction and intracellular contents leakage in a focus and time-dependent method. Particularly, essentially the most cell-selective peptide L1GA5Okay exhibited potent antimicrobial exercise towards rifampin-resistant E. coli (RRE) and prevented the emergence of rifampin resistance in Enterobacter.
Moreover, L1GA5Okay was able to reversing rifampin resistance in RRE by way of the outer membrane permeabilization when utilized in mixture with rifampin. Collectively, our outcomes steered that the newly designed peptides are hopeful antibiotic options, and the utilization of them as an adjuvant to stop and reverse antibiotic resistance is a promising technique for tackling the chance of drug-resistant Gram-negative micro organism.
Diminished Efflux Pumps Expression of Pseudomonas Aeruginosa with Satureja Khuzistanica Important Oil
Background: Efflux pumps comparable to MexEF-OprN and mexXY-OprM play an necessary position within the resistance of Pseudomonas Aeruginosa (P. aeruginosa) to antibiotics. The current examine aimed to evaluate the lowered expression of efflux pump genes of P. aeruginosa with Satureja Khuzistanica important oil (SKEO).
Strategies: The current cross-sectional examine was carried out in 2016 on the Microbiology Laboratory of Baqiyatallah College of Medical Sciences, Tehran, Iran. The disk diffusion methodology was used for susceptibility testing of gentamicin and norfloxacin. Minimal inhibitory focus (MIC) was decided for gentamicin and norfloxacin. The antibacterial efficacy of SKEO was outlined by figuring out the MIC values utilizing the microdilution methodology. In vitro, the synergistic interplay of SKEO mixed with gentamicin or norfloxacin was examined through checkerboard assay and outlined as a fractional inhibitory focus index. The reverse transcription-polymerase chain response approach was used to measure adjustments within the expression of the efflux pump genes. The information have been analyzed utilizing SPSS software program model 16.0, and P<0.05 was thought-about statistically important.
10mg/mL Gentamicin Sulphate Solution |
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| MBS2567644-5x10mL | MyBiosource | 5x10mL | EUR 370 |
Gentamicin sulphate, Plant Culture Teste |
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| PCT1118-1G | EWC Diagnostics | 1 unit | EUR 10.58 |
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Description: Gentamicin sulphate, Plant Culture Teste |
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Gentamicin sulphate, Plant Culture Teste |
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| PCT1118-5G | EWC Diagnostics | 1 unit | EUR 47.74 |
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Description: Gentamicin sulphate, Plant Culture Teste |
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Gentamicin Sulphate (GM) for tissue culture |
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| 50827 | Sisco Laboratories | 1 Gms | EUR 7.2 |
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Description: Part B |
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Gentamicin Sulfate |
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| 08975-81 | NACALAI TESQUE | 1G | EUR 77 |
Gentamicin Sulfate |
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| 08975-94 | NACALAI TESQUE | 5G | EUR 266 |
Gentamicin Sulfate |
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| 16637-32 | NACALAI TESQUE | 25G | EUR 630 |
Gentamicin sulfate |
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| 329895 | MedKoo Biosciences | 1.0g | EUR 250 |
Gentamicin Sulfate |
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| 40710020-1 | Glycomatrix | 5 g | EUR 26.88 |
Gentamicin Sulfate |
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| 40710020-2 | Glycomatrix | 10 g | EUR 46.61 |
Gentamicin Sulfate |
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| 40710020-3 | Glycomatrix | 25 g | EUR 76.8 |
Gentamicin sulfate |
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| B1270-1G | Biovision | each | EUR 170.4 |
Gentamicin sulfate |
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| B1270-25G | Biovision | each | EUR 1136.4 |
Gentamicin sulfate |
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| B1270-5G | Biovision | each | EUR 405.6 |
Gentamicin sulfate |
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| GA7939 | Glentham Life Sciences | 1g | EUR 115.8 |
GENTAMICIN SULFATE |
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| G570 | PhytoTechnology Laboratories | 10G | EUR 32.75 |
Gentamicin (sulfate) |
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| HY-A0276 | MedChemExpress | 500mg | EUR 142.8 |
Gentamicin sulfate |
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| GA7939-1 | Glentham Life Sciences | 1 | EUR 15.9 |
Gentamicin sulfate |
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| GA7939-10 | Glentham Life Sciences | 10 | EUR 71.1 |
Gentamicin sulfate |
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| GA7939-10G | Glentham Life Sciences | 10 g | EUR 122.4 |
Gentamicin sulfate |
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| GA7939-1G | Glentham Life Sciences | 1 g | EUR 55.2 |
Gentamicin sulfate |
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| GA7939-25 | Glentham Life Sciences | 25 | EUR 126.5 |
Gentamicin sulfate |
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| GA7939-25G | Glentham Life Sciences | 25 g | EUR 189.6 |
Gentamicin sulfate |
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| GA7939-5 | Glentham Life Sciences | 5 | EUR 47.4 |
Gentamicin sulfate |
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| GA7939-5G | Glentham Life Sciences | 5 g | EUR 93.6 |
Gentamicin sulfate |
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| T1326-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Gentamicin sulfate |
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Gentamicin sulfate |
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| T1326-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Gentamicin sulfate |
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Gentamicin sulfate |
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| T1326-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Gentamicin sulfate |
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Gentamicin sulfate |
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| T1326-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Gentamicin sulfate |
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Gentamicin sulfate |
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| T1326-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Gentamicin sulfate |
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Gentamycin sulphate |
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| MB288-1G | EWC Diagnostics | 1 unit | EUR 9.14 |
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Description: Gentamycin sulphate |
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Gentamycin sulphate |
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| MB288-5G | EWC Diagnostics | 1 unit | EUR 40.99 |
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Description: Gentamycin sulphate |
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Gentamicin X2 Sulfate |
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| 565235 | MedKoo Biosciences | 1.0mg | EUR 380 |
Gentamicin Sulfate EP |
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| G007-25G | TOKU-E | 25 g | EUR 309.86 |
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Description: C21H43N5O7 • H2SO4 |
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Gentamicin Sulfate EP |
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| G007-5G | TOKU-E | 5 g | EUR 128.8 |
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Description: C21H43N5O7 • H2SO4 |
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Gentamicin X2 Sulfate |
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| G360605 | Toronto Research Chemicals | 0.5mg | EUR 2223 |
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Description: 57793-88-1 |
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Gentamicin B Sulfate |
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| G360650 | Toronto Research Chemicals | 25mg | EUR 25000 |
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Description: 43169-50-2 |
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Gentamicin Sulfate - 1g |
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| PM-A4120/1 | Biosera France - Medical Scientific Equipment | 1g | EUR 5.89 |
Gentamicin Sulfate - 5g |
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| PM-A4120/5 | Biosera France - Medical Scientific Equipment | 5g | EUR 18.7 |
Gentamicin Sulfate USP |
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| G006-25G | TOKU-E | 25 g | EUR 215.79 |
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Description: N/A |
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Gentamicin Sulfate USP |
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| G006-5G | TOKU-E | 5 g | EUR 64.06 |
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Description: N/A |
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Gentamicin sulfate salt |
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| 20-abx082235 | Abbexa |
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Gentamicin sulfate salt |
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| abx082235-100l | Abbexa | 100 µl | EUR 162.5 |
Gentamicin sulfate salt |
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| abx082235-1ml | Abbexa | 1 ml | Ask for price |
Gentamicin sulfate salt |
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| abx082235-200l | Abbexa | 200 µl | EUR 212.5 |
Gentamicin Solution, Gentamicin Solution, 50 mg/mL |
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| CCM1123-010 | Bio Basic | 10 mL | EUR 76.86 |
Gentamicin |
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| MD025-1PK | EWC Diagnostics | 1 unit | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| MD061-1PK | EWC Diagnostics | 1 unit | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| EM025-150ST | EWC Diagnostics | 1 unit | EUR 164.38 |
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Description: Gentamicin |
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Gentamicin |
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| EM061-150ST | EWC Diagnostics | 1 unit | EUR 169.41 |
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Description: Gentamicin |
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Gentamicin |
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| G272 | ABM | 10ml | EUR 70 |
Gentamicin |
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| T25447-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| T25447-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| T25447-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| T25447-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| T25447-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Gentamicin |
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Gentamicin |
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| MBS5775176-5mg | MyBiosource | 5(mg | EUR 915 |
Gentamicin |
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| MBS5775176-5x5mg | MyBiosource | 5x5(mg | EUR 3970 |
Gentamicin |
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| HY-A0276A | MedChemExpress | Get quote | Ask for price |
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Description: Gentamicin, an orally active aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits DNase I with an IC50 of 0.57 mM[1][2][3][4]. |
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Gentamycin (Gentamicin) Sulfate USP |
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| MBS651447-100g | MyBiosource | 100g | EUR 570 |
Gentamycin (Gentamicin) Sulfate USP |
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| MBS651447-1kg | MyBiosource | 1kg | EUR 1495 |
Gentamycin (Gentamicin) Sulfate USP |
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| MBS651447-25g | MyBiosource | 25g | EUR 440 |
Gentamycin (Gentamicin) Sulfate USP |
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| MBS651447-500g | MyBiosource | 500g | EUR 860 |
Gentamycin (Gentamicin) Sulfate USP |
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| MBS651447-5g | MyBiosource | 5g | EUR 210 |
0.1g Gentamicin Sulfate Powder |
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| 61-098-RA | Scientific Laboratory Supplies | EACH | EUR 58.37 |
1g Gentamicin Sulfate Powder |
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| 61-098-RF | Scientific Laboratory Supplies | EACH | EUR 76.38 |
Gentamicin(GM) |
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| AT022 | Unibiotest | 1mg | EUR 1134 |
Gentamicin(GM) |
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| AG022 | Unibiotest | 1 mg | EUR 627.6 |
Gentamicin (AP) |
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| MBS6247946-01mL | MyBiosource | 0.1(mL | EUR 880 |
Gentamicin (AP) |
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| MBS6247946-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamicin (PE) |
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| MBS6251839-01mL | MyBiosource | 0.1(mL | EUR 880 |
Gentamicin (PE) |
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| MBS6251839-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamycin (Gentamicin) |
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| MBS600426-025mg | MyBiosource | 0.25mg | EUR 580 |
Gentamycin (Gentamicin) |
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| MBS600426-05mg | MyBiosource | 0.5mg | EUR 965 |
Gentamycin (Gentamicin) |
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| MBS600426-5x05mg | MyBiosource | 5x0.5mg | EUR 4185 |
Gentamycin (Gentamicin) |
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| MBS603541-05mg | MyBiosource | 0.5mg | EUR 1285 |
Gentamycin (Gentamicin) |
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| MBS603541-5x05mg | MyBiosource | 5x0.5mg | EUR 5640 |
Gentamycin (Gentamicin) |
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| MBS605789-1mg | MyBiosource | 1mg | EUR 530 |
Gentamycin (Gentamicin) |
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| MBS605789-5x1mg | MyBiosource | 5x1mg | EUR 2230 |
Gentamycin (Gentamicin) |
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| MBS614836-025mL | MyBiosource | 0.25mL | EUR 490 |
Gentamycin (Gentamicin) |
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| MBS614836-5x025mL | MyBiosource | 5x0.25mL | EUR 2055 |
Gentamycin (Gentamicin) |
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| MBS614871-1mg | MyBiosource | 1mg | EUR 450 |
Gentamycin (Gentamicin) |
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| MBS614871-5x1mg | MyBiosource | 5x1mg | EUR 1865 |
Gentamycin (Gentamicin) |
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| MBS615263-025mL | MyBiosource | 0.25mL | EUR 515 |
Gentamycin (Gentamicin) |
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| MBS615263-5x025mL | MyBiosource | 5x0.25mL | EUR 2155 |
Gentamicin Sulfate, Animal-Free |
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| 19771-01 | NACALAI TESQUE | 1G | EUR 53.2 |
Gentamicin Sulfate, Animal-Free |
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| 19771-14 | NACALAI TESQUE | 5G | EUR 168 |
Gentamicin Sulfate, Animal-Free |
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| 19771-72 | NACALAI TESQUE | 25G | EUR 630 |
Gentamicin [KLH] |
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| DAG4484 | Creative Diagnostics | 1mg | EUR 1248 |
Gentamicin [HRP] |
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| DAGA-032H | Creative Diagnostics | 1mg | EUR 1248 |
Gentamicin [OVA] |
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| DAG4468O | Creative Diagnostics | 1 mg | EUR 520 |
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Description: Synthetic |
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Gentamicin (HRP) |
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| MBS6250887-01mL | MyBiosource | 0.1(mL | EUR 880 |
Gentamicin (HRP) |
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| MBS6250887-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamicin (APC) |
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| MBS6268799-01mL | MyBiosource | 0.1mL | EUR 880 |
Gentamicin (APC) |
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| MBS6268799-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamicin C1a |
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| HY-148286 | MedChemExpress | 10 mg | EUR 77.92 |
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Description: Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2]. |
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Gentamicin (FITC) |
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| MBS6249892-01mL | MyBiosource | 0.1(mL | EUR 880 |
Gentamicin (FITC) |
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| MBS6249892-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamicin C1 Sulfate EvoPure® |
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| G031-10MG | TOKU-E | 10 mg | EUR 569.63 |
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Description: C21H43N5O7• xH2SO4 (lot specific) |
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Gentamicin C2 sulfate EvoPure® |
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| G033-10MG | TOKU-E | 10 mg | EUR 569.63 |
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Description: C20H41N5O7• xH2SO4(lot specific) |
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Gentamicin A sulfate EvoPure® |
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| G035-10MG | TOKU-E | 10 mg | EUR 311.7 |
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Description: C18H36N4O10• xH2SO4 (lot specific) |
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Gentamicin X2 sulfate EvoPure® |
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| G036-2.5MG | TOKU-E | 2.5 mg | EUR 36 |
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Description: C19H38N4O10• xH2SO4 (lot specific) |
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Gentamicin X2 sulfate EvoPure® |
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| G036-PleaseContactusforPricing | TOKU-E | Please Contact us for Pricing | EUR 36 |
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Description: C19H38N4O10• xH2SO4 (lot specific) |
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Gentamicin-HRP |
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| 65-IG10 | Fitzgerald | 1 mg | EUR 525 |
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Description: Conjugated Gentamicin-HRP hapten |
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Gentamicin-BSA |
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| 80-1453 | Fitzgerald | 1 mg | EUR 592 |
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Description: BSA conjugated Gentamicin Hapten |
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Gentamicin-BSA |
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| 80-1454 | Fitzgerald | 1 mg | EUR 592 |
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Description: BSA conjugated Gentamicin Hapten |
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Gentamicin-OVA |
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| 80-1455 | Fitzgerald | 1 mg | EUR 592 |
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Description: OVA conjugated Gentamicin Hapten |
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Gentamicin-OVA |
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| 80-1456 | Fitzgerald | 1 mg | EUR 592 |
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Description: OVA conjugated Gentamicin Hapten |
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Gentamicin-BSA |
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| 80-IG10 | Fitzgerald | 25 mg | EUR 325 |
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Description: Conjugated Gentamicin-BSA hapten |
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Gentamicin-BSA |
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| MBS7041680-01mg | MyBiosource | 0.1mg | EUR 135 |
Gentamicin-BSA |
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| MBS7041680-1mg | MyBiosource | 1mg | EUR 435 |
Gentamicin-BSA |
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| MBS7041680-5x1mg | MyBiosource | 5x1mg | EUR 1915 |
Gentamicin-OVA |
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| MBS7041681-01mg | MyBiosource | 0.1mg | EUR 135 |
Gentamicin-OVA |
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| MBS7041681-1mg | MyBiosource | 1mg | EUR 435 |
Gentamicin-OVA |
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| MBS7041681-5x1mg | MyBiosource | 5x1mg | EUR 1915 |
Gentamicin-BSA |
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| MBS537343-25mg | MyBiosource | 25mg | EUR 505 |
Gentamicin-BSA |
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| MBS537343-5x25mg | MyBiosource | 5x25mg | EUR 2115 |
Gentamicin-HRP |
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| MBS537743-1mg | MyBiosource | 1mg | EUR 680 |
Gentamicin-HRP |
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| MBS537743-5x1mg | MyBiosource | 5x1mg | EUR 2915 |
Gentamicin Sulfate 10 mg/ml - 10ml |
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| LM-A4111/10 | Biosera France - Medical Scientific Equipment | 10ml | EUR 5.5 |
Gentamicin Sulfate 10 mg/ml - 100ml |
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| LM-A4111/100 | Biosera France - Medical Scientific Equipment | 100ml | EUR 20.19 |
Gentamicin Sulfate 50 mg/ml - 10ml |
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| LM-A4112/10 | Biosera France - Medical Scientific Equipment | 10ml | EUR 6.11 |
Gentamicin Sulfate 50 mg/ml - 100ml |
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| LM-A4112/100 | Biosera France - Medical Scientific Equipment | 100ml | EUR 30.25 |
Gentamicin (Biotin) |
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| MBS6248965-01mL | MyBiosource | 0.1(mL | EUR 880 |
Gentamicin (Biotin) |
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| MBS6248965-5x01mL | MyBiosource | 5x0.1mL | EUR 3805 |
Gentamicin Sulfate Salt (C Complex) |
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| G360600 | Toronto Research Chemicals | 1g | EUR 63 |
|
Description: 1405-41-0 |
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Gentamicin Sulfate Solution(10mg/ml) |
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| 16672-04 | NACALAI TESQUE | 10ML | EUR 16.1 |
Gentamicin Sulfate Solution(50mg/ml) |
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| 11980-14 | NACALAI TESQUE | 10ML | EUR 56 |
Gentamicin Antibody |
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| abx021011-200ug | Abbexa | 200 ug | EUR 393.6 |
Gentamicin Antibody |
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| abx021012-1mg | Abbexa | 1 mg | EUR 1144.8 |
Gentamicin Antibody |
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| abx021013-1mg | Abbexa | 1 mg | EUR 577.2 |
Gentamicin antibody |
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| 10-1541 | Fitzgerald | 100 ug | EUR 350 |
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Description: Mouse monoclonal Gentamicin antibody |
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Gentamicin antibody |
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| 10-G02A | Fitzgerald | 500 ug | EUR 231.75 |
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Description: Mouse monoclonal Gentamicin antibody |
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Gentamicin antibody |
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| 20-GG15 | Fitzgerald | 250 ul | Ask for price |
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Description: Goat polyclonal Gentamicin antibody |
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Gentamicin antibody |
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| 20-GR15 | Fitzgerald | 250 ul | EUR 165 |
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Description: Rabbit polyclonal Gentamicin antibody |
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Gentamicin antibody |
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| 20C-CR1031S | Fitzgerald | 1 ml | EUR 174 |
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Description: Sheep polyclonal Gentamicin antiserum |
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Gentamicin Antibody |
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| 20-abx210193 | Abbexa |
|
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Gentamicin Antibody |
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| GWB-5E5C0A | GenWay Biotech | 1 ml | Ask for price |
Gentamicin Antibody |
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| GWB-5F0BB2 | GenWay Biotech | 1 mg | Ask for price |
Gentamicin Antibody |
|||
| GWB-300476 | GenWay Biotech | 0.2 mg | Ask for price |
Gentamicin Antibody |
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| GWB-Q00939 | GenWay Biotech | 1 mg | Ask for price |
Gentamicin Antibody |
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| GWB-Q00940 | GenWay Biotech | 1 mg | Ask for price |
Gentamicin, Antibody |
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| GWB-F36A07 | GenWay Biotech | 1 mg | Ask for price |
Outcomes: The MIC values of SKEO have been within the vary of 6 to 12 µg/mL. Within the presence of sub-inhibitory concentrations (1.16 to 2 MIC) of SKEO, synergistic results have been revealed utilizing the checkerboard methodology. The impact of norfloxacin and gentamicin elevated as much as 8-fold. The expression of mexY and mexE was lowered after therapy with SKEO.
